The last two decades have witnessed an increase in international society's interest in the phenomenon of trafficking in human beings. This article aims to present the activities of national and regional organisations dealing with this problem that function in the legislative, supervisory and operational areas. The limited scope of this paper does not allow for the discussion of all government organisations undertaking initiatives for combating trafficking in human beings. For this reason, the study is limited to the most important ones, which engage in a wide range of activities. At the same time, the presented review of the forms of activity of international organisations and adopted legal instruments is a synthetic and by no means an exhaustive one.